News

May
15th
Diffusion tensor imaging in blepharospasm and blepharospasm-oromandibular dystonia.
Yang J, Luo C, Song W, Guo X, Zhao B, Chen X, Huang X, Gong Q, Shang HF. - May 15, 2014

Patterns of white matter (WM) abnormalities and correlation with clinical features in patients with blepharospasm (BSP) and patients with blepharospasm-oromandibular dystonia (BOM) remain unknown. Using voxel-based analysis, diffusion behaviors of WM including fractional anisotropy (FA), mean diffusivity (MD) and eigenvalues were compared between 20 BSP patients vs. 11 healthy controls (HCs) and 11 patients with BOM vs. 11 HCs. Correlation analyses were performed to assess possible association between diffusion behaviors of significantly different areas and clinical measures.
- Read more about Diffusion tensor imaging in blepharospasm and blepharospasm-oromandibular dystonia.
May
15th
SGCZ mutations are unlikely to be associated with myoclonus dystonia.
Peall KJ, Ritz K, Waite AJ, Groen JL, Morris HR, Baas F, Blake DJ, Tijssen MA. - May 15, 2014

BACKGROUND: Myoclonus dystonia syndrome (MDS) is a hyperkinetic movement disorder caused, in a proportion of cases, by mutations of the maternally imprinted epsilon-sarcoglycan gene (SGCE). SGCE mutation rates vary between cohorts, suggesting genetic heterogeneity. E- and ζ-sarcoglycan are both expressed in brain tissue. In this study we tested whether zeta-sarcoglycan gene (SGCZ) mutations also contribute to this disorder.
- Read more about SGCZ mutations are unlikely to be associated with myoclonus dystonia.
May
15th
Treatment and physiology in Parkinson's disease and dystonia: using transcranial magnetic stimulation to uncover the mechanisms of action.
Wagle Shukla A, Vaillancourt DE. - May 15, 2014

Transcranial magnetic stimulation (TMS) has served as an important technological breakthrough in the field of the physiology of movement disorders over the last three decades. TMS has grown popular owing to the ease of application as well as its painless and noninvasive character. The technique has provide important insights into understanding the pathophysiology of movement disorders, particularly Parkinson's disease and dystonia.
- Read more about Treatment and physiology in Parkinson's disease and dystonia: using transcranial magnetic stimulation to uncover the mechanisms of action.
May
15th
The clinical spectrum of laryngeal dystonia includes dystonic cough: Observations of a large series.
Payne S, Tisch S, Cole I, Brake H, Rough J, Darveniza P. - May 15, 2014

Laryngeal dystonia is a movement disorder of the muscles within the larynx, which most commonly manifests as spasmodic dysphonia (SD). Rarer reported manifestations include dystonic respiratory stridor and dyscoordinate breathing. Laryngeal dystonia has been treated successfully with botulinum neurotoxin (BTX) injections since 1984. We reviewed prospectively collected data in a consecutive series of 193 patients with laryngeal dystonia who were seen at St. Vincent's Hospital between 1991 and 2011. Patient data were analyzed in Excel, R, and Prism.
- Read more about The clinical spectrum of laryngeal dystonia includes dystonic cough: Observations of a large series.
May
15th
Bilateral pallidal stimulation for sargoglycan epsilon negative myoclonus.
Sidiropoulos C, Mestre T, Hutchison W, Moro E, Valencia A, Poon YY, Fallis M, Rughani AI, Kalia SK, Lozano AM, Lang AE - May 15, 2014

We report on the clinical efficacy of bilateral globus pallidus internus deep brain stimulation in two patients with myoclonus dystonia/essential myoclonus who lack mutations in the epsilon sarcoglycan gene. The primary outcome measures were the Burke-Fahn-Marsden Dystonia Scale motor severity and the Unified Myoclonus Rating Scale scores, and the secondary outcome measure was the 36-item Short Form Health Survey score at the last postoperative follow up. Neuronal firing rates were also calculated from microelectrode recordings.
- Read more about Bilateral pallidal stimulation for sargoglycan epsilon negative myoclonus.

News

Diffusion tensor imaging in blepharospasm and blepharospasm-oromandibular dystonia.

SGCZ mutations are unlikely to be associated with myoclonus dystonia.

Treatment and physiology in Parkinson's disease and dystonia: using transcranial magnetic stimulation to uncover the mechanisms of action.

The clinical spectrum of laryngeal dystonia includes dystonic cough: Observations of a large series.

Bilateral pallidal stimulation for sargoglycan epsilon negative myoclonus.

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