News

September
1st
The combined treatment with orbital and pretarsal botulinum toxin injections in the management of poorly responsive blepharospasm.
Esposito M, Fasano A, Crisci C, Dubbioso R, Iodice R, Santoro L. - September 1, 2013

Blepharospasm (BS) is a focal dystonia involving involuntary contractions of muscles around the eyes. Botulinum toxin (BoNT) is the most effective treatment for BS and the technique of injection changes depending on the clinical picture. Usually typical BS benefits from the injection in the orbital part of the orbicularis oculi (OOc) muscle (orbital injection), while BoNT injection in the pretarsal part of OOc muscle is helpful especially for the atypical BS (opening eyelid apraxia).
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September
1st
Pre-Synaptic Release Deficits in a DYT1 Dystonia Mouse Model.
Yokoi F, Cheetham CC, Campbell SL, Sweatt JD, Li Y. - September 1, 2013

DYT1 early-onset generalized torsion dystonia (DYT1 dystonia) is an inherited movement disorder caused by mutations in one allele of DYT1 (TOR1A), coding for torsinA. The most common mutation is a trinucleotide deletion (ΔGAG), which causes a deletion of a glutamic acid residue (ΔE) in the C-terminal region of torsinA. Although recent studies using cultured cells suggest that torsinA contributes to protein processing in the secretory pathway, endocytosis, and the stability of synaptic proteins, the nature of how this mutation affects synaptic transmission remains unclear.
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September
1st
Interhemispheric difference of pallidal local field potential activity in cervical dystonia.
Lee JR, Kiss ZH. - September 1, 2013

BACKGROUND: Cervical dystonia (CD) produces involuntary neck muscle contractions that result in abnormal and often asymmetrical postures of the head and neck. Basal ganglia oscillatory activity in the 3-12 Hz band correlating with involuntary muscle activity suggests a role in the pathophysiology of primary dystonia. Despite the asymmetrical postures seen with CD, no comparison of interhemispheric differences of pallidal local field potential (LFP) activity has been reported.
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August
31st
Special concerns in defining, studying, and treating dystonia in children.
Mink JW - August 31, 2013

Dystonia is movement disorder with many diverse underlying etiologies. Some of those etiologies manifest at specific stages of development or at specific ages. Others may present early in life and evolve as the individual develops. The appearance of symptoms during a time of nervous system development poses special challenges to the neurologist.
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August
31st
The focal dystonias: Current views and challenges for future research.
Jinnah HA, Berardelli A, Comella C, Defazio G, Delong MR, Factor S, Galpern WR, Hallett M, Ludlow CL, Perlmutter JS, Rosen AR; D - August 31, 2013

The most common forms of dystonia are those that develop in adults and affect a relatively isolated region of the body. Although these adult-onset focal dystonias are most prevalent, knowledge of their etiologies and pathogenesis has lagged behind some of the rarer generalized dystonias, in which the identification of genetic defects has facilitated both basic and clinical research. This summary provides a brief review of the clinical manifestations of the adult-onset focal dystonias, focusing attention on less well understood clinical manifestations that need further study.
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News

The combined treatment with orbital and pretarsal botulinum toxin injections in the management of poorly responsive blepharospasm.

Pre-Synaptic Release Deficits in a DYT1 Dystonia Mouse Model.

Interhemispheric difference of pallidal local field potential activity in cervical dystonia.

Special concerns in defining, studying, and treating dystonia in children.

The focal dystonias: Current views and challenges for future research.

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